Discovery of a broad-spectrum, fluorinated macrobicyclic antibiotic through chemical synthesis.

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Discovery of a broad-spectrum, fluorinated macrobicyclic antibiotic through chemical synthesis.

Practical Synthesis of Macrobicyclic Thiolincosamines

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.

A method for tritiation of iboxamycin permits measurement of its ribosomal binding

A synthetic antibiotic class overcoming bacterial multidrug resistance.